Non-Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

Alternative monocytes settle in for the long term.

Abstract

is generally accepted that monocytes recruited from the bloodstream play a major part in inflammation. However, the ultimate fate of these elicited cells is much less clear. In particular, it has been controversial whether recruited monocytes can subsequently differentiate into resident macrophages with homeostatic properties. In the current issue of Nature Immunology, Gundra et al. present evidence showing that monocytes recruited to the peritoneal cavity by a type 2 inflammatory reaction can differentiate into macrophages with the phenotypic and transcriptional signature of resident peritoneal macrophages1.