Non-Primate Monocytes - CD14, CD16 - Ziegler-Heitbrock

The March of Monocytes in Atherosclerosis: One Cell at a Time.

Abstract

Monocytes contribute critically to the initiation, progression, and thrombus formation stages of atherosclerosis and myocardial infarction.1 Early arterial injury triggers an innate immune response, which promotes the entry of bone marrow–derived monocytes into the intima (Figure [A]).2 Risk factors for atherosclerosis that boost this recruitment of mononuclear phagocytes include hypercholesterolemia and the newly identified clonal hematopoiesis of indeterminate potential.3 Infiltrating monocytes in the intima progress to lesional macrophages and can proliferate in the intima where they promote plaque progression